Automated Headspace Analysis

Driven by continuous innovation, WILCO has continuously developed the HSA technology since 2003 when the first inline HSA system was installed. With the latest generation of lasers, a new milestone in terms of speed and detection limits has been reached.

SPECTRA HSX

The verification of quality relevant attributes of the headspace conditions e.g. in lyophilized and liquid filled vials, requires non-destructive and robust inspection technologies. The SPECTRA HSX platform impresses with its highly sensitive laser system and the flexibility to be configured for individual requirements.

Latest generation of HSA lasers

With our latest generation of Headspace Analysis heads new mile stones in terms of sensitivity and acqusition time are set.

Online calibration system

To verfify the correct calibration of the HSA system during multiple-hour production runs, an online calibration system is integrated and ensures maximum process reliability.

Smooth container transport

The transport system is designed to minimize pressure and friction on the containers to reduce the risk of scratches or other damage.

The SPECTRA HSX is a compact inspection platform developed for non-destructive Headspace Analysis of pharmaceutical packages with modified headspace conditions. Due to the continuous developments of the laser system it can be used for the highest requirements and with the flexibilty of integrating additional inspection technologies. The system is capable of testing 2ml vials to LVP bottles or other packaging types. Depending on the given conditions and requirements, up to two test heads can be integrated. By increasing the number of test heads either the throughput or the sensitiviy can be improved.
 

Inspection of multiple gases

Optionally, two different laser heads can be integrated to check for both the partial pressure of oxygen or carbon dioxide and the total pressure inside the test sample. Additionally, a NIR spectroscopy module for moisture detection in lyophilizates or barcode readers for container identification can be integrated.

Specifications and highlights

  • Throughput up to 400 pcs/min
  • 2ml up to 100 ml containers
  • Non-destructive head space analysis of vials, syringes, ampoules
  • Deterministic CCIT method preferred acc. USP<1207>
  • Applicable for glass and plastic containers
  • Simple format changeover
  • Design according GMP guidelines
  • Data Handling in compliance with 21 CFR part 11
  • Reliable product handling
  • Toolless format changeover
  • Optional integration of visual inspection systems
  • Optional integration of 2D DataMatrix Code reader
  • Optional integration of NIR Module for residual moisture and lyo defects

R HSA

The verification of quality relevant attributes of the headspace conditions e.g. in lyophilized and liquid filled vials, requires non-destructive and robust inspection technologies. The R HSA platform is designed to meet the highest requirements in terms of sensitivity and throughput for automated Headspace Analysis.

Latest generation of HSA lasers

With our latest Head Space Analysis generation, we are setting new milestones in terms of sensitivity and inspection speed.

Integrated online calibration system

To verify the correct calibration of the HSA system during multiple-hour production runs, an online calibration tool was integrated to ensure maximum process reliability.

Integration of multiple test heads

The R HSA platform can accommodate up to 10 test heads providing the highest sensititity.

The R HSA is an inspection platform developed for non-destructive Headspace Analysis for pharmaceutical packages with modified headspace conditions. Headspace Analysis may be used for nitrogen purging efficiency, vacuum verification or container closure integrity testing (CCIT).

Due to the continuous developments of the laser headspace system the R HSA qualifies for the highest requirements and provides the option to add further inspection technologies. Depending on the given conditions, up to ten test heads can be integrated. By increasing the number of test heads both the throughput and the sensitiviy are improved.

Integration of additional inspection methods for Vials

The integration of NIR spectroscopy modules for moisture detection in lyophilizates or barcode readers for container identification is optional. The combination with other inspection platforms such as the automated visual inspection platform is also possible.

Specifications and highlights

  • Up to 600/min
  • 2ml up to 100 ml containers
  • Non-destructive head space analysis of vials, syringes, ampoules
  • Non-destructive, deterministic test method preferred acc. USP1207
  • Applicable for glass and plastic containers
  • Applicable for liquid, lyophilized and solid products
  • Designed according to GMP guidelines
  • Data Handling in compliance with 21 CFR part 11
  • Reliable product handling
  • Toolless format changeover
  • Optional integration of visual inspection systems
  • Optional integration of 2D DataMatrix Code reader
  • Optional integration of NIR Module for residual moisture and lyo defects